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| Id | 777 | |
| Author | Fancourt D., Williamon A., Carvalho L.A., Steptoe A., Dow R., Lewis I. | |
| Title | Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers | |
| Reference | Fancourt D., Williamon A., Carvalho L.A., Steptoe A., Dow R., Lewis I.; Singing modulates mood, stress, cortisol, cytokine and neuropeptide activity in cancer patients and carers ;ecancermedicalscience vol:10.0 issue: page: |
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| Link to article | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978999439&doi=10.3332%2fecancer.2016.631&partnerID=40&md5=4633e1495a3b0982747421f00a9c7bc7 |
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| Abstract | There is growing evidence that psychosocial interventions can have psychological benefits for people affected by cancer, including improved symptoms of mental health and wellbeing and optimised immune responses. However, despite growing numbers of music interventions, particularly singing, in cancer care, there is less research into their impact. We carried out a multicentre single-arm preliminary study to assess the impact of singing on mood, stress and immune response in three populations affected by cancer: carers (n = 72), bereaved carers (n = 66) and patients (n = 55). Participants were excluded if pregnant or if they were currently being treated with chemotherapy, radiotherapy or oral immunosuppressive drugs. Participants were regular participants in five choirs across South Wales and took part in one hour of group singing. Before and after singing, visual analogue mood scales, stress scales and saliva samples testing for cortisol, beta-endorphin, oxytocin and ten cytokines were taken. Across all five centres and in all four participant groups, singing was associated with significant reductions in negative affect and increases in positive affect (p <.01) alongside significant increases in cytokines including GM-CSF, IL17, IL2, IL4 and sIL-2rα (all p <.01). In addition, singing was associated with reductions in cortisol, beta-endorphin and oxytocin levels. This study provides preliminary evidence that singing improves mood state and modulates components of the immune system. Further work is needed to ascertain how this differs for more specific patient groups and whether repeat exposure could lead to meaningful, longitudinal effects. © the authors; licensee ecancermedicalscience. |
There is growing evidence that psychosocial interventions can have psychological benefits for people affected by cancer, including improved symptoms of mental health and wellbeing and optimised immune responses. Participants were excluded if pregnant or if they were currently being treated with chemotherapy radiotherapy or oral immunosuppressive drugs. ecancer : Background Over the past years more than studies have explored the combined psychological and biological value of psychosocial interven- tions from mindfulness to yoga to the arts for cancer patients survivors and carers . There is nevertheless evidence to suggest that music interventions could have a combined effect on the mental health and immune function of people affected by cancer. Given the correlations found between cortisol and both oxytocin and beta-endorphin and their correlations with one another and the negative correlations between the neuropeptides and cytokines which mirrored the relationship between cortisol and the cytokines it seems likely that the decrease found here was as part of a generalised down-regulation of stress response which may have over-ridden any social bonding or happiness-associated increase.
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